| CASE SERIES |
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| Year : 2023 | Volume
: 3
| Issue : 1 | Page : 2-6 |
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Tuberous sclerosis complex presenting as afebrile encephalopathy: Diverse etiology, unitary approach
Prarthana Kharod1, Devendra Mishra2, Deepti Chawla1, Anurag Pandey1, Monica Juneja2
1 Department of Pediatrics, Maulana Azad Medical College, Delhi, India
2 Child Development Center, Maulana Azad Medical College, Delhi, India
Correspondence Address:
Dr. Anurag Pandey
Department of Pediatrics, Maulana Azad Medical College, Delhi - 110 002
India
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/ipcares.ipcares_191_22
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Background: Tuberous sclerosis complex (TSC) is a multisystem genetic disorder with a range of physical manifestations that require regular evaluation, surveillance, and management. Central nervous system manifestations are the major cause of morbidity and mortality in TSC patients. Encephalopathy, which may be due to multiple etiologies, maybe seen sometimes in these patients. Clinical Description: We are sharing a series of three cases, presenting to us within a 6-month period with encephalopathy, who were admitted and treated by us. Etiologies were identified in all three cases with variable spectrum from nonconvulsive status epilepticus to autistic regression to valproate-associated hyperammonemia. Management: All three patients admitted with us were treated as per clinical guidelines for respective etiologies. All patients respond well to treatment and were discharged and are under regular follow-up. Conclusion: There are various etiologies for encephalopathy in a child with TSC. Therefore, thorough history, examination, and investigations should be carried out in every child with TSC to find out the likely cause of encephalopathy, and treatment should be initiated according to the underlying cause. |
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